I thought the second season premiere was a mixed bag.
It didn't have that epic feel of the first season and the first hour seemed padded, as though marking time until the shocker at the end of the episode. I think it would have been better if they'd just kept the episode at an hour, trimming the fat and keeping it tense. The search for the little girl seemed to drag on forever, while the exchange between Shane and Lori was far too short and surprisingly unmoving. Even Andrea's exchange with Dale and him basically guilting her into leaving the CDC compound at the end of last season seemed oddly stiff.
Let's not forget what made this one of the best shows on TV -- the writing, the acting and the character development. All three seemed just the slightest bit off in this episode, to me.
Still. It's only the first ep of the new season. I can forgive a slight misstep in an otherwise stellar series.